Here are the 49 US AI startups that have raised $100M or more in 2025 – TechCrunch

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Here are the 49 US AI startups that have raised $100M or more in 2025

By Rebecca Szkutak, 12:48 PM PST · November 26, 2025

Last year was monumental for the AI industry in the U.S. and beyond.

There were 49 startups that raised funding rounds worth $100 million or more in 2024, per our count at TechCrunch; three companies raised more than one “mega-round,” and seven companies raised rounds that were $1 billion in size or larger.

How will 2025 compare? As we enter near the final month of the year, 2025 has already matched 2024 in terms of companies raising rounds that are $100 million and larger. There are also significantly more companies that have raised multiple funding rounds larger than $100 million this year compared to last.

Here are all the U.S. AI companies that have raised $100 million this year:

November

Anysphere, the maker of viral vibe-coding platform Cursor, raised $2.3 billion in a funding round that valued the company at $29.3 billion. The round was announced on November 13 and is the company’s second funding round this year.
Parallel, which builds web infrastructure for AI agents, raised a $100 million Series A round that was announced on November 12. The round was co-led by Index Ventures and Kleiner Perkins.
Healthcare AI agent startup Hippocratic AI raised a $126 million Series C round that valued the company at $3.5 billion. The round was the company’s second this year, was announced on November 3, and was led by Avenir Growth.

October

Fireworks AI, a platform that allows users to build AI applications using open source models, raised a $250 million Series C round that was announced on October 28. The round valued the company at $4 billion.
Enterprise AI startup Uniphore is valued at $2.5 billion after a $260 million Series F round that was announced on October 22. The round included Snowflake Ventures, Nvidia, Databricks Ventures, and AMD, among others.
Sesame, a voice AI company, raised a $250 million Series B round co-led by Sequoia and Spark Capital. The round was announced on October 21 and also included SignalRank as a participant.
Cambridge, Massachusetts’s based OpenEvidence, which builds an AI chatbot for the medical field, raised its second funding round of 2025. The $200 million Series C round was announced on October 20 and valued the company at $6 billion.
Lila Sciences, which is looking to build a science superintelligence platform, announced its second funding round of 2025 on October 14. The $350 million Series A round was co-led by Braidwell and Collective Global.
DeepSeek competitor Reflection AI announced its second mega-round of the year on October 9. The $2 billion Series B round valued the company at $8 billion and was led by Nvidia.
EvenUp, which builds AI for the personal injury legal field, announced a $150 million Series E round that valued the company at more $2 billion on October 7. The round was led by Bessemer with participation from Lightspeed, Bain Capital and SignalFire, among others.